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4955 Directors Place, Suite 300
San Diego, CA, 92121
United States

8582034200

The ADC Specialty Company

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产品

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ADC连接子

联宁生物制药提供不同结构和功能的多种连接子,可用于抗体和药物的偶联的连接子。更重要的是,联宁自主开发的拥有完全知识产权的连接子可以将药物精确且可控地偶联到抗体上,更易实现批次间的产品质量控制。为更好地支持客户的药物开发,联宁还提供连接子定制设计和合成服务。

For structures, click here>>>

产品目录号 产品名称 Cas 号 纯度 可提供数量
VC1001 Val-Cit-PAB 159857-79-1 95% mg - 500g
VC1002 Fmoc-Val-Cit-PAB 159858-22-7 95% mg - 500g
VC1003 Fmoc-Val-Cit-PAB-PNP 863971-53-3 95% mg - 500g
VC1004 MC-Val-Cit-PAB-PNP 159857-81-5 95% mg-100g
FK1001 Phe-Lys(Trt)-PAB 95% mg - kg
FK1002 Fmoc-Phe-Lys(Trt)-PAB 95% mg - kg
FK1003 Fmoc-Phe
-Lys(Trt)-PAB-PNP
1116086-09-9 95% mg - kg
AN1001 Ala-Ala-Asn-PAB TFA salt 95% mg - kg
AN1002 Fmoc-Ala-Ala-Asn-PAB-PNP 95% mg - kg
H1001 Fmoc-Gly3-Val-Cit-PAB 95% mg-100g
H1002 Fmoc-Gly3-Val-Cit-PAB-PNP 95% mg-100g
D1000 SMCC 64987-85-5 98% 500mg-500g
DS1001 Py-ds-Prp-OSu 95% mg - kg
DS1003 Py-ds-dmBut-OSu 95% mg - 100g
DS1013 Py-ds-dmBut-OPFP 95% mg - 100g
DS1011 Py-ds-Prp-OPFP 95% mg - kg
MA1000 MAL-HA-OSu 95% mg - kg
MA2011 MAL-di-EG-OPFP 95% mg - kg
MA2012 MAL-tri-EG-OPFP 95% mg - kg
MA2013 MAL-tetra-EG-OPFP 95% mg - kg
AZ1011 N3-di-EG-OPFP 95% mg - kg
AZ1012 N3-tri-EG-OPFP 95% mg - kg
AZ1013 N3-tetra-EG-OPFP 95% mg - kg
AL1001 ALD-BZ-OSu 95% mg - kg
AL1003 ALD-di-EG-OSu 95% mg - kg
AL1005 ALD-tetra-EG-OSu 95% mg - kg
AL1013 ALD-di-EG-OPFP 95% mg - kg
AL1015 ALD-tetra-EG-OPFP 95% mg - kg
HA1011 PHA-di-EG-OPFP 95% mg - kg
HA1013 PHA-tetra-EG-OPFP 95% mg - kg
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ADC细胞毒素药物

从抗体到靶向抗体药物偶联物的合成过程极具有挑战性。为了设计出高效的抗体药物偶联物,毒素的选择是至关重要的。联宁生物制药提供各种各样的微管蛋白抑制剂和DNA烷基化试剂,这些试剂已被证实是抗体药物偶联物负载的有效细胞毒素。对下面列出的这些毒素, 联宁可以提供毫克级至100克级的高质量产品。

For structures, click here>>>

产品目录号 产品名称 Cas 号 纯度 可提供数量
T1001 Dolastatin 10 110417-88-4 98% mg - 100g
T1002 Monomethyl Dolastatin 10 203849-91-6 98% mg - 100g
T1003 Auristatin E 160800-57-7 98% mg - 100g
T1004 Monomethyl Auristatin E 474645-27-7 98% mg - 100g
T1005 Auristatin F 163768-50-1 98% mg - 100g
T1006 Monomethyl Auristatin F 745017-94-1 98% mg - 100g
T1007 HTI-286 228266-40-8 95% mg - g
T1008 Tubulysin M 205304-86-5 95% mg - g
T1009 Maytansinoid AP-3 66547-09-9 85% mg
T1109 Maytansinol 57103-68-1 95% mg - 100g
LN-T-4582 DM1 139504-50-0 98% mg - 100g
LN-T-7544 DM4 799840-96-3 98% mg - 10g
T1102 Boc-Val-Dil-Dap-OH 95% mg - kg
T1202 Boc-Val-Dil-Dap-Phe-OMe 95% mg - kg
T1222 Boc-Val-Dil-Dap-Doe 95% mg - kg
T1224 Boc-Val-Dil-Dap-Nrp 95% mg - kg
T1302 Boc-N-Me-Val-Val-Dil-Dap-OH 95% mg - kg
T1108 Tubulysin IM-1 95% mg - 100g
T1208 Tubulysin IM-2 95% mg - 100g
T1308 Tubulysin IM-3 95% mg - 100g
D1001 Duocarmycin SA 152785-82-5 95% mg - g
D1007 Duocarmycin TM 95% mg - g
D1008 Duocarmycin MA 95% mg - g
D1009 Duocarmycin DM 95% mg - g
D4000 Nemorubicin 108852-90-0 95% mg - 10 g
D4001 PNU-159682 202350-68-3 >90% mg -10 g
LN-T-6888 Calicheamicin g1 108212-75-5 >95% mg-100mg
D4006 N-Acetyl-Calicheamicin g1 108212-76-6
>95%
mg-100g
D4007 a-Amanitin 23109-05-9 >95% mg-g
D4008 PBD-dimer 1222490-34-7 >90% mg-100mg

易用的细胞毒素     (SET™)

联宁生物制药提供安全易用的毒素(SET™),这是一种可以快速筛选抗体药物偶联物的新型研究工具。SET™产品线包括很多已验证的连接子-毒素,分别装入预包装好的小瓶中。每个SET™小瓶含有约200纳摩的连接子-毒素,按药物/抗体比(DAR)为3-4计算的话, 足够偶联5毫克抗体。客户不需要称重或分装连接子-毒素,只需按照产品说明书上提供的溶解方案,即可使用SET™。SET™不仅易于使用,更重要的是可以最大限度地减少实验过程中暴露毒素的风险。目前,SET™可用于以下类别的偶联反应:

    ❖胺反应SET™ 
    ❖硫醇反应SET™ 
    ❖点击反应SET™ 
    ❖转肽酶反应 SET™ 

For structures, click here>>>

胺反应 SET™
产品目录号 产品名称 数量 单价
SET0100 OSu-Glu-vc-PAB-MMAE 200 nmol $500
SET0101 SMCC-DM1 200 nmol $500
SET0102 SPDB-DM4 200 nmol $650
SET0103 OSu-PEG4-vc-PAB-DMEA
Duocarmycin SA
200 nmol $750
SET0104 Mylotarg-linker 200 nmol $950
SET0105 OSu-Glu-vc-PAB-MMAD 200 nmol $500
SET0106 Sulfo-SPDB-DM4 200 nmol $950
SET0107 IMGN779-linker NEW 200 nmol $2,200
硫醇反应SET™
产品目录号 产品名称 数量 单价
SET0201 MC-vc-PAB-MMAE 200 nmol $500
SET0202 MC-MMAF 200 nmol $500
SET0203 MC-DM1 200 nmol $700
SET0204 MC-MMD-10 200 nmol $600
SET0205 MA-PEG4-vc-PAB-DMEA-
duocarmycin SA
200 nmol $750
SET0206 MC-vc-PAB-C6-a-amanitin 200 nmol $850
SET0207 MC-cleavable-linker-a-amanitin 200 nmol $600
SET0208 MC-vc-PAB-DMEA-(PEG2)-
duocarmycin SA
200 nmol $800
SET0209 MC-vc-PAB-Tubulysin M 200 nmol $800
SET0210 MC-vc-PAB-Monomethyl
dolastatin10
200 nmol $500
SET0211 MA-PEG4-VC-PAB-DMAE-PNU159682 200 nmol $950
SET0212 MA-PEG4-VA-PBD 200 nmol $1,100
SET0213 MC-vc-PAB-MMAF 200 nmol $500
SET0214 MC-vc-PAB-MMAD 200 nmol $500
SET0215 MC-vc-PAB-Auristatin 0101 200 nmol $900
SET0216 MA-PEG8-VA-PAB-SG3199 200 nmol $1,950
SET0217 CL2A-SN 38 200 nmol $800
SET0218 MC-GGFG-DX8951 200 nmol $950
SET0219 MEDI4276_linker payload 200 nmol $1,100
点击反应SET™
产品目录号 产品名称 数量 单价
SET0301 DBCO-PEG4-vc-PAB-MMAE 200 nmol $650
SET0302 DBCO-PEG4-MMAF 200 nmol $750
SET0303 DBCO-PEG4-Ahx-DM1 200 nmol $750
SET0304 DBCO-PEG4-vc-PAB-
Duocarmycin SA
200 nmol $900
SET0305 DBCO-PEG4-vc-PAB-(PEG2)-
Duocarmycin SA
200 nmol $1,050
SET0306 DBCO-PEG4-VA-PBD 200 nmol $1,100
SET0307 DBCO-PEG4-vc-PAB-MMAF 200 nmol $650
SET0308 DBCO-PEG4-vc-PAB-MMAD 200 nmol $650
转肽酶反应 SET™
产品目录号 产品名称 数量 单价
SET0401 Gly3-vc-PAB-MMAE 200 nmol $850
SET0402 Gly3-MMAF 200 nmol $850
SET0403 Gly5-Ahx-DM1 200 nmol $950
SET0404 PNU159682-EDA-Gly3 200 nmol $1,100

ADC筛选试剂盒

联宁生物制药提供研究阶段抗体药物偶联物体外活性的筛选服务。公司的细胞库拥有超过100个癌细胞株,可以帮助客户评估抗体药物偶联物的细胞毒性和治疗潜力。公司还可以根据客户的需求灵活安排用这些细胞株来筛选抗体药物偶联物。

联宁生物制药制备了目前市面上常用的抗体药物偶联物,如T-DM1,brentuximab vedotin,VEGR2-ADC等,作为抗体药物偶联物评估的对照物,为客户评估抗体药物偶联物生物仿制药提供方便。

联宁生物制药开发的以蛋白A和蛋白G的PSKA™和PSKG™的抗体药物偶联物预筛选试剂盒,在不做偶联的情况下, 可以快速鉴定适合抗体药物偶联物研发用的抗体。使用这些试剂盒,可以直接筛选初级抗体,略去单独将毒素偶联到抗体上的过程。我们提供的PSK筛选试剂盒包括业界常用毒素,如MMAE,MMAF,DM1和duocarmycin。

产品目录号 产品名称 产品说明 数量 单价
LEV-PSKA-100 ADC pre-screening kit A Four vials containing Protein A preloaded with
1x MMAE (cleavable linker)
1x MMAF (non-cleavable linker)
1x MCC-DM1 (non-cleavable linker)
1x Duocarmycin (non-cleavable linker)
4x100 µL $ 900.00
LEV-ADM-100 Protein A-DM1 Protein A preloaded with MCC-DM1 (non-cleavable linker) 100 µL $ 300.00
LEV-AME-100 Protein A-MMAE Protein A preloaded with MMAE (cleavable linker) 100 µL $ 300.00
LEV-AMF-100 Protein A-MMAF Protein A preloaded with MMAF (non-cleavable linker) 100 µL $ 300.00
LEV-ADC-100 Protein A-Duocarmycin Protein A preloaded with Duocarmycin (non-cleavable linker) 100 µL $ 400.00
LEV-ACC-100 Protein A-Calicheamicin Protein A preloaded with Calicheamicin (cleavable linker) 100 µL $ 400.00
LEV-APB-100 Protein A-PBD Protein A preloaded with PBD 100 µL $ 400.00
LEV-PSKG-100 ADC pre-screening kit G Four vials containing Protein A preloaded with
1x MMAE (cleavable linker)
1x MMAF (non-cleavable linker)
1x MCC-DM1 (non-cleavable linker)
1x Duocarmycin (non-cleavable linker)
4x100 µL $ 900.00
LEV-GDM-100 Protein G-DM1 Protein G preloaded with MCC-DM1 (non-cleavable linker) 100 µL $ 300.00
LEV-GME-100 Protein G-MMAE Protein G preloaded with MMAE (cleavable linker) 100 µL $ 300.00
LEV-GMF-100 Protein G-MMAF Protein G preloaded with MMAF (non-cleavable linker) 100 µL $ 300.00
LEV-GDC-100 Protein G-Duocarmycin Protein G preloaded with Duocarmycin (non-cleavable linker) 100 µL $ 400.00
LEV-GAM-100 Protein G-Amanitin Protein G preloaded with Amanitin (cleavable linker) 100 µL $ 400.00
LEV-GAL-100 Protein G-Amanitin Protein G preloaded with Amanitin (Levena cleaveable linker) 100 µL $ 400.00
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抗细胞毒性药物抗体

联宁生物制药开发了各种抗细胞毒性药物抗体用来支持客户的临床前药物研究。目前,提供的抗体包括针对不同类别的细胞毒性药物的抗毒素(药物)单克隆和多克隆抗体。这些产品仅限于科研,不能用于临床诊断。

  • MMAE / MMAF
  • DM1 / DM4
  • 加利车霉素
  • 多卡霉素
  • PNU
  • 氨基
产品目录号 产品名称 毒素类型 微升 单价 毫克/毫升
LEV-PAE1-100 Rabbit Anti-vc-PAB-MMAE pAb Tubulin Inhibitor 100 $ 500.00 1
LEV-PAE1-500 500 $ 1,875.00
LEV-MAE1-100 Mouse Anti-vc-PAB-MMAE mAb (B11F11) Tubulin Inhibitor 100 $ 900.00 1
LEV-MAE1-500 500 $ 3,375.00
LEV-PAF1-100 Rabbit Anti-MMAF pAb Tubulin Inhibitor 100 $ 500.00 1
LEV-PAF1-500 500 $ 1,875.00
LEV-MAF1-100 Mouse Anti-MMAF mAb (F3B11) Tubulin Inhibitor 100 $ 900.00 1
LEV-MAF1-500 500 $ 3,375.00
LEV-MAE3-100 Mouse Anti-MMAE / F mAb (B12A2) Tubulin Inhibitor 100 $ 900.00 1
LEV-MAE3-500 500 $ 3,375.00
LEV-MAF3-100 Mouse Anti-MMAE /F mAb (C12A1) Tubulin Inhibitor 100 $ 900.00 1
LEV-MAF3-500 500 $ 3,375.00
LEV-PDM1-100 Rabbit Anti-DM1/4 pAb Tubulin Inhibitor 100 $ 500.00 1
LEV-PDM1-500 500 $ 1,875.00
LEV-MDM1-100 Mouse Anti-DM1/4 mAb (F1D5) Tubulin Inhibitor 100 $ 900.00 1
LEV-MDM1-500 500 $ 3,375.00
LEV-MDM2-100 Mouse Anti-DM1/4 mAb (G2F3) Tubulin Inhibitor 100 $ 900.00 1
LEV-MDM2-500 500 $ 3,375.00
LEV-PCA1-100 Rabbit Anti-Calicheamicin pAb DNA Damaging 100 $ 750.00 0.5
LEV-PCA1-500 500 $ 2,800.00
LEV-MCA1-100 Mouse Anti-Calicheamicin mAb (B1G9) DNA Damaging 100 $ 1,250.00 0.5
LEV-MCA1-500 500 $ 4,700.00
LEV-MCA2-100 Mouse Anti-Calicheamicin mAb (C1F12) DNA Damaging 100 $ 1,250.00 0.5
LEV-MCA2-500 500 $ 4,700.00
LEV-PDU1-100 Rabbit Anti-Duocarmycin pAb DNA Damaging 100 $ 750.00 0.5
LEV-PDU1-500 500 $ 2,800.00
LEV-MDU3-100 Mouse Anti-Duocarmycin mAb (E11A1) DNA Damaging 100 $ 900.00 0.5
LEV-MDU3-500 500 $ 3,375.00
LEV-MDU1-100 Mouse Anti-Duocarmycin mAb (H7A9) DNA Damaging 100 $ 900.00 0.5
LEV-MDU1-500 500 $ 3,375.00
LEV-MDU2-100 Mouse Anti-Duocarmycin mAb (E6B3) DNA Damaging 100 $ 900.00 0.5
LEV-MDU2-500 500 $ 3,375.00
LEV-PPN1-100 Rabbit Anti-PNU-159682 pAb DNA Damaging 100 $ 750.00 0.5
LEV-PPN1-500 500 $ 2,800.00
LEV-MPN1-100 Mouse Anti-PNU-159682 mAb (F7F2) DNA Damaging 100 $ 900.00 0.5
LEV-MPN1-500 500 $ 3,375.00
LEV-MPN2-100 Mouse Anti-PNU-159682 mAb (C1E3) DNA Damaging 100 $ 900.00 0.5
LEV-MPN2-500 500 $ 3,375.00
LEV-MPN3-100 Mouse Anti-PNU-159682 mAb (D12H11) DNA Damaging 100 $ 900.00 0.5
LEV-MPN3-500 500 $ 3,375.00
LEV-PAM1-100 Rabbit Anti-Amanitin pAb RNA Polymerase II and III Inhibitor 100 $ 650.00 0.5
LEV-PAM1-500 500 $ 2,450.00
LEV-MAM1-100 Mouse Anti-Amanitin mAb (H3E1) RNA Polymerase II and III Inhibitor 100 $ 1,100.00 0.5
LEV-MAM1-500 500 $ 4,100.00
LEV-MAM2-100 Mouse Anti-Amanitin mAb (H12D6) RNA Polymerase II and III Inhibitor 100 $ 1,100.00 0.5
LEV-MAM2-500 500 $ 4,100.00
LEV-MAM3-100 Mouse Anti-Amanitin mAb (C2C4) RNA Polymerase II and III Inhibitor 100 $ 1,100.00 0.5
LEV-MAM3-500 500 $ 4,100.00
LEV-PSN1-100 Rabbit Anti-SN38 pAb DNA Topoisomerase I Inhibitor 100 $ 650.00 0.5
LEV-PSN1-500 500 $ 2,450.00
LEV-MSN1-100 Mouse Anti-SN38 mAb DNA Topoisomerase I Inhibitor 100 $ 900.00 0.5
LEV-MSN1-500 500 $ 3,375.00