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4955 Directors Place, Suite 300
San Diego, CA, 92121
United States

8582034200

The ADC Specialty Company

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Products

ADC Linkers

Levena Biopharma’s linkers embody a wide range of structures and functionalities, designed for the conjugation of a broad spectrum of antibodies and toxins. More importantly, our linkers allow the conjugation process to be performed in a precise and controlled fashion, easing the batch-to-batch product manufacturing and quality control. We use conventional chemistries to provide customized design and synthesis of linkers to support your drug development.

For structures, click here>>>

Catalog # Product Name CAS No. Purity Quantity
VC1001 Val-Cit-PAB 159857-79-1 95% mg - 500g
VC1002 Fmoc-Val-Cit-PAB 159858-22-7 95% mg - 500g
VC1003 Fmoc-Val-Cit-PAB-PNP 863971-53-3 95% mg - 500g
VC1004 MC-Val-Cit-PAB-PNP 159857-81-5 95% mg-100g
FK1001 Phe-Lys(Trt)-PAB 95% mg - kg
FK1002 Fmoc-Phe-Lys(Trt)-PAB 95% mg - kg
FK1003 Fmoc-Phe
-Lys(Trt)-PAB-PNP
1116086-09-9 95% mg - kg
AN1001 Ala-Ala-Asn-PAB TFA salt 95% mg - kg
AN1002 Fmoc-Ala-Ala-Asn-PAB-PNP 95% mg - kg
H1001 Fmoc-Gly3-Val-Cit-PAB 95% mg-100g
H1002 Fmoc-Gly3-Val-Cit-PAB-PNP 95% mg-100g
D1000 SMCC 64987-85-5 98% 500mg-500g
DS1001 Py-ds-Prp-OSu 95% mg - kg
DS1003 Py-ds-dmBut-OSu 95% mg - 100g
DS1013 Py-ds-dmBut-OPFP 95% mg - 100g
DS1011 Py-ds-Prp-OPFP 95% mg - kg
MA1000 MAL-HA-OSu 95% mg - kg
MA2011 MAL-di-EG-OPFP 95% mg - kg
MA2012 MAL-tri-EG-OPFP 95% mg - kg
MA2013 MAL-tetra-EG-OPFP 95% mg - kg
AZ1011 N3-di-EG-OPFP 95% mg - kg
AZ1012 N3-tri-EG-OPFP 95% mg - kg
AZ1013 N3-tetra-EG-OPFP 95% mg - kg
AL1001 ALD-BZ-OSu 95% mg - kg
AL1003 ALD-di-EG-OSu 95% mg - kg
AL1005 ALD-tetra-EG-OSu 95% mg - kg
AL1013 ALD-di-EG-OPFP 95% mg - kg
AL1015 ALD-tetra-EG-OPFP 95% mg - kg
HA1011 PHA-di-EG-OPFP 95% mg - kg
HA1013 PHA-tetra-EG-OPFP 95% mg - kg

ADC Payloads

Levena Biopharma offers a comprehensive assortment of tubulin inhibitors and DNA-alkylating agents that are proven and used commercially as payloads. These toxins listed below are available in purity that is suitable for use as an API; we also can provide cGMP production of 100 gram quantities. Levena Biopharma in addition has a portfolio of proprietary toxins available for testing and licensing upon request. 

For structures, click here>>>

Catalog # Product Name CAS No. Purity Quantity
T1001 Dolastatin 10 110417-88-4 98% mg - 100g
T1002 Monomethyl Dolastatin 10 203849-91-6 98% mg - 100g
T1003 Auristatin E 160800-57-7 98% mg - 100g
T1004 Monomethyl Auristatin E 474645-27-7 98% mg - 100g
T1005 Auristatin F 163768-50-1 98% mg - 100g
T1006 Monomethyl Auristatin F 745017-94-1 98% mg - 100g
T1007 HTI-286 228266-40-8 95% mg - g
T1008 Tubulysin M 205304-86-5 95% mg - g
T1009 Maytansinoid AP-3 66547-09-9 85% mg
T1109 Maytansinol 57103-68-1 95% mg - 100g
LN-T-4582 DM1 139504-50-0 98% mg - 100g
LN-T-7544 DM4 799840-96-3 98% mg - 10g
T1102 Boc-Val-Dil-Dap-OH 95% mg - kg
T1202 Boc-Val-Dil-Dap-Phe-OMe 95% mg - kg
T1222 Boc-Val-Dil-Dap-Doe 95% mg - kg
T1224 Boc-Val-Dil-Dap-Nrp 95% mg - kg
T1302 Boc-N-Me-Val-Val-Dil-Dap-OH 95% mg - kg
T1108 Tubulysin IM-1 95% mg - 100g
T1208 Tubulysin IM-2 95% mg - 100g
T1308 Tubulysin IM-3 95% mg - 100g
D1001 Duocarmycin SA 152785-82-5 95% mg - g
D1007 Duocarmycin TM 95% mg - g
D1008 Duocarmycin MA 95% mg - g
D1009 Duocarmycin DM 95% mg - g
D4000 Nemorubicin 108852-90-0 95% mg - 10 g
D4001 PNU-159682 202350-68-3 >90% mg -10 g
LN-T-6888 Calicheamicin g1 108212-75-5 >95% mg-100mg
D4006 N-Acetyl-Calicheamicin g1 108212-76-6
>95%
mg-100g
D4007 a-Amanitin 23109-05-9 >95% mg-g
D4008 PBD-dimer 1222490-34-7 >90% mg-100mg

Safe & Easy Toxin (SET™)

Levena Biopharma offers Safe & Easy Toxin (SET™), an intuitive research tool for rapid antibody-drug conjugation experiments. SET™s ready to use to validated linker-toxins in small, pre-packaged vials equipped with septum. Each SET™ vial contains approximately 200nmol of linker-toxin, sufficient to conjugate up to 5mg antibody with a drug-to-antibody ratio (DAR) of 3-4. No weighing or aliquoting of the linker-toxin is necessary. Simply follow the dissolution protocol provided with the product and the SET™ is ready to use. The SET™ format is easy to use and, at the same time, minimizes the exposure of the lab space to hazardous toxins. Currently, SET™s are available for the following categories:

     ❖ Amine Reactive SET™ 
     ❖ Thiol Reactive SET™
     ❖ Click Reactive SET™
     ❖ Sortase Reactive SET™

For structures, click here>>>

Amine Reactive SET™
Catalog # Product Size Unit Price
SET0100 OSu-Glu-vc-PAB-MMAE 200 nmol $500
SET0101 SMCC-DM1 200 nmol $500
SET0102 SPDB-DM4 200 nmol $650
SET0103 OSu-PEG4-vc-PAB-DMEA
Duocarmycin SA
200 nmol $750
SET0104 Mylotarg-linker 200 nmol $950
SET0105 OSu-Glu-vc-PAB-MMAD 200 nmol $500
SET0106 Sulfo-SPDB-DM4 200 nmol $950
SET0107 IMGN779-linker NEW 200 nmol $2,200
Thiol Reactive SET™
Catalog # Product Size Unit Price
SET0201 MC-vc-PAB-MMAE 200 nmol $500
SET0202 MC-MMAF 200 nmol $500
SET0203 MC-DM1 200 nmol $700
SET0204 MC-MMD-10 200 nmol $600
SET0205 MA-PEG4-vc-PAB-DMEA-
duocarmycin SA
200 nmol $750
SET0206 MC-vc-PAB-C6-a-amanitin 200 nmol $850
SET0207 MC-cleavable-linker-a-amanitin 200 nmol $600
SET0208 MC-vc-PAB-DMEA-(PEG2)-
duocarmycin SA
200 nmol $800
SET0209 MC-vc-PAB-Tubulysin M 200 nmol $800
SET0210 MC-vc-PAB-Monomethyl
dolastatin10
200 nmol $500
SET0211 MA-PEG4-VC-PAB-DMAE-PNU159682 200 nmol $950
SET0212 MA-PEG4-VA-PBD 200 nmol $1,100
SET0213 MC-vc-PAB-MMAF 200 nmol $500
SET0214 MC-vc-PAB-MMAD 200 nmol $500
SET0215 MC-vc-PAB-Auristatin 0101 200 nmol $900
SET0216 MA-PEG8-VA-PAB-SG3199 200 nmol $1,950
SET0217 CL2A-SN 38 200 nmol $800
SET0218 MC-GGFG-DX8951 200 nmol $950
Click Reactive SET™
Catalog # Product Size Unit Price
SET0301 DBCO-PEG4-vc-PAB-MMAE 200 nmol $650
SET0302 DBCO-PEG4-MMAF 200 nmol $750
SET0303 DBCO-PEG4-Ahx-DM1 200 nmol $750
SET0304 DBCO-PEG4-vc-PAB-
Duocarmycin SA
200 nmol $900
SET0305 DBCO-PEG4-vc-PAB-(PEG2)-
Duocarmycin SA
200 nmol $1,050
SET0306 DBCO-PEG4-VA-PBD 200 nmol $1,100
SET0307 DBCO-PEG4-vc-PAB-MMAF 200 nmol $650
SET0308 DBCO-PEG4-vc-PAB-MMAD 200 nmol $650
Sortase Reactive SET™
Catalog # Product Size Unit Price
SET0401 Gly3-vc-PAB-MMAE 200 nmol $850
SET0402 Gly3-MMAF 200 nmol $850
SET0403 Gly5-Ahx-DM1 200 nmol $950
SET0404 PNU159682-EDA-Gly3 200 nmol $1,100

ADC Screening Kits

Levena Biopharma offers screening services to study the in vitro activity of the ADCs. We maintain a library of over 100 cancer cell lines to evaluate potency and therapeutic potential of our clients’ ADCs. We also offer flexible arrangements for screening ADCs on these cell lines.

Levena Biopharma possesses a collection of popular ADCs such as T-DM1, brentuximab vedotin, VEGR- ADC, etc. to gauge clients’ biosimilars against benchmark ADCs.

Levena Biopharma has developed pre-screening kits using Protein A and Protein G, PSKA™ and PSKG™, that can expedite the identification of antibodies suitable for ADC candidates. With these kits, primary antibodies can be screened without individual conjugation to cytotoxic agents. We offer PSKs with widely-used industry standard toxins such as MMAE, MMAF, DM1, and duocarmycin.

Catalog # Product Description Quantity Price
LEV-PSKA-100 ADC pre-screening kit A Four vials containing Protein A preloaded with
1x MMAE (cleavable linker)
1x MMAF (non-cleavable linker)
1x MCC-DM1 (non-cleavable linker)
1x Duocarmycin (non-cleavable linker)
4x100 µL $ 900.00
LEV-ADM-100 Protein A-DM1 Protein A preloaded with MCC-DM1 (non-cleavable linker) 100 µL $ 300.00
LEV-AME-100 Protein A-MMAE Protein A preloaded with MMAE (cleavable linker) 100 µL $ 300.00
LEV-AMF-100 Protein A-MMAF Protein A preloaded with MMAF (non-cleavable linker) 100 µL $ 300.00
LEV-ADC-100 Protein A-Duocarmycin Protein A preloaded with Duocarmycin (non-cleavable linker) 100 µL $ 400.00
LEV-ACC-100 Protein A-Calicheamicin Protein A preloaded with Calicheamicin (cleavable linker) 100 µL $ 400.00
LEV-APB-100 Protein A-PBD Protein A preloaded with PBD 100 µL $ 400.00
LEV-PSKG-100 ADC pre-screening kit G Four vials containing Protein A preloaded with
1x MMAE (cleavable linker)
1x MMAF (non-cleavable linker)
1x MCC-DM1 (non-cleavable linker)
1x Duocarmycin (non-cleavable linker)
4x100 µL $ 900.00
LEV-GDM-100 Protein G-DM1 Protein G preloaded with MCC-DM1 (non-cleavable linker) 100 µL $ 300.00
LEV-GME-100 Protein G-MMAE Protein G preloaded with MMAE (cleavable linker) 100 µL $ 300.00
LEV-GMF-100 Protein G-MMAF Protein G preloaded with MMAF (non-cleavable linker) 100 µL $ 300.00
LEV-GDC-100 Protein G-Duocarmycin Protein G preloaded with Duocarmycin (non-cleavable linker) 100 µL $ 400.00
LEV-GAM-100 Protein G-Amanitin Protein G preloaded with Amanitin (cleavable linker) 100 µL $ 400.00
LEV-GAL-100 Protein G-Amanitin Protein G preloaded with Amanitin (Levena cleaveable linker) 100 µL $ 400.00
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Anti-payload Antibodies

Levena Biopharma offers a set antibodies against a variety of payloads. Currently, the following anti-payload monoclonal and polyclonal antibodies with specificity against different categories of cytotoxic drugs are available.  These products are for research purposes only, not for use in diagnostics.

  •       MMAE/MMAF
  •       DM1/DM4
  •       Calicheamicin
  •       Duocarmycin
  •       PNU
  •       Amanitin
Catalog # Product Payload Category µL Price mg/mL
LEV-PAE1-100 Rabbit Anti-vc-PAB-MMAE pAb Tubulin Inhibitor 100 $ 500.00 1
LEV-PAE1-500 500 $ 1,875.00
LEV-MAE1-100 Mouse Anti-vc-PAB-MMAE mAb (B11F11) Tubulin Inhibitor 100 $ 900.00 1
LEV-MAE1-500 500 $ 3,375.00
LEV-PAF1-100 Rabbit Anti-MMAF pAb Tubulin Inhibitor 100 $ 500.00 1
LEV-PAF1-500 500 $ 1,875.00
LEV-MAF1-100 Mouse Anti-MMAF mAb (F3B11) Tubulin Inhibitor 100 $ 900.00 1
LEV-MAF1-500 500 $ 3,375.00
LEV-MAE3-100 Mouse Anti-MMAE / F mAb (B12A2) Tubulin Inhibitor 100 $ 900.00 1
LEV-MAE3-500 500 $ 3,375.00
LEV-MAF3-100 Mouse Anti-MMAE /F mAb (C12A1) Tubulin Inhibitor 100 $ 900.00 1
LEV-MAF3-500 500 $ 3,375.00
LEV-PDM1-100 Rabbit Anti-DM1/4 pAb Tubulin Inhibitor 100 $ 500.00 1
LEV-PDM1-500 500 $ 1,875.00
LEV-MDM1-100 Mouse Anti-DM1/4 mAb (F1D5) Tubulin Inhibitor 100 $ 900.00 1
LEV-MDM1-500 500 $ 3,375.00
LEV-MDM2-100 Mouse Anti-DM1/4 mAb (G2F3) Tubulin Inhibitor 100 $ 900.00 1
LEV-MDM2-500 500 $ 3,375.00
LEV-PCA1-100 Rabbit Anti-Calicheamicin pAb DNA Damaging 100 $ 750.00 0.5
LEV-PCA1-500 500 $ 2,800.00
LEV-MCA1-100 Mouse Anti-Calicheamicin mAb (B1G9) DNA Damaging 100 $ 1,250.00 0.5
LEV-MCA1-500 500 $ 4,700.00
LEV-MCA2-100 Mouse Anti-Calicheamicin mAb (C1F12) DNA Damaging 100 $ 1,250.00 0.5
LEV-MCA2-500 500 $ 4,700.00
LEV-PDU1-100 Rabbit Anti-Duocarmycin pAb DNA Damaging 100 $ 750.00 0.5
LEV-PDU1-500 500 $ 2,800.00
LEV-MDU3-100 Mouse Anti-Duocarmycin mAb (E11A1) DNA Damaging 100 $ 900.00 0.5
LEV-MDU3-500 500 $ 3,375.00
LEV-MDU1-100 Mouse Anti-Duocarmycin mAb (H7A9) DNA Damaging 100 $ 900.00 0.5
LEV-MDU1-500 500 $ 3,375.00
LEV-MDU2-100 Mouse Anti-Duocarmycin mAb (E6B3) DNA Damaging 100 $ 900.00 0.5
LEV-MDU2-500 500 $ 3,375.00
LEV-PPN1-100 Rabbit Anti-PNU-159682 pAb DNA Damaging 100 $ 750.00 0.5
LEV-PPN1-500 500 $ 2,800.00
LEV-MPN1-100 Mouse Anti-PNU-159682 mAb (F7F2) DNA Damaging 100 $ 900.00 0.5
LEV-MPN1-500 500 $ 3,375.00
LEV-MPN2-100 Mouse Anti-PNU-159682 mAb (C1E3) DNA Damaging 100 $ 900.00 0.5
LEV-MPN2-500 500 $ 3,375.00
LEV-MPN3-100 Mouse Anti-PNU-159682 mAb (D12H11) DNA Damaging 100 $ 900.00 0.5
LEV-MPN3-500 500 $ 3,375.00
LEV-PAM1-100 Rabbit Anti-Amanitin pAb RNA Polymerase II and III Inhibitor 100 $ 650.00 0.5
LEV-PAM1-500 500 $ 2,450.00
LEV-MAM1-100 Mouse Anti-Amanitin mAb (H3E1) RNA Polymerase II and III Inhibitor 100 $ 1,100.00 0.5
LEV-MAM1-500 500 $ 4,100.00
LEV-MAM2-100 Mouse Anti-Amanitin mAb (H12D6) RNA Polymerase II and III Inhibitor 100 $ 1,100.00 0.5
LEV-MAM2-500 500 $ 4,100.00
LEV-MAM3-100 Mouse Anti-Amanitin mAb (C2C4) RNA Polymerase II and III Inhibitor 100 $ 1,100.00 0.5
LEV-MAM3-500 500 $ 4,100.00